AI in addiction research

Drug discovery and large-dataset studies.

1. Study

   An AI search for cocaine addiction medicines led experts to ketamine, a drug already being studied

   Source date February 23, 2023 · AI ranking of 1,430 FDA-approved drugs, review by a 7-member expert panel, then a retrospective health-record comparison with propensity score matching. Not pre-registered; the authors call it exploratory. · 7,742 patients given anesthesia (3,871 ketamine, 3,871 other anesthetics) and 7,910 patients with depression (3,955 ketamine, 3,955 antidepressants or midazolam), after matching

   Experts chose ketamine from an AI shortlist for cocaine addiction. Records tied it to more remission diagnoses, but just 1% to 3% of ketamine patients had one.